曼尼托尔引起的咳反应被吸入的萨尔布塔摩尔减少
Mustafaa Wahab1, Ruth P Cusack1, Caitlin Stevens1
1McMaster University, Department of Medicine, Division of Respirology, Hamilton, Canada.
ERJ open research
|March 25, 2025
概括
在喘患者和健康人群中,萨尔布塔摩尔可以减少曼尼托尔诱导的咳. 在健康人群中,这种效果独立于呼吸道口径的变化,这表明沙布塔摩尔的作用超出了平滑肌肉放松的范围.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床药理学 临床药理学
- 神经科学是一个神经科学.
背景情况:
- 吸入曼尼托尔会在喘时引起支气管收缩和咳.
- 沙尔布塔摩尔对急性喘中呼吸道神经的影响尚不清楚.
- 独立于支气管扩张,调查沙布塔摩尔对咳反射的影响至关重要.
研究的目的:
- 确定沙布塔是否能减少过敏性喘患者 (AAs) 和健康对照者 (HCs) 的曼尼托尔引起的咳.
- 评估萨尔布塔摩尔的抗咳作用是否独立于气道口径的变化.
- 探索沙布塔摩尔对咳反射的潜在非支气管扩张机制.
主要方法:
- 这是一项双盲,随机,安慰剂控制,交叉研究.
- 包括20名轻度过敏的,从未服用过类固醇的喘患者和20名健康对照.
- 曼尼托尔 (含有和不含有沙布塔摩尔) 引起的最大咳 (Emax) 的比较.
主要成果:
- 在AA和HC中,萨尔布塔摩尔显著降低了曼尼托尔引起的Emax.
- 在AAs中,沙布塔摩尔减弱了曼尼托尔诱导的FEV1降低.
- 在HC中,萨尔布塔摩尔降低了咳反应,独立于FEV1变化.
结论:
- 萨尔布塔摩尔有效地减少了因吸入曼尼托尔而引起的咳,在喘患者和健康人群中.
- 在健康人群中,萨尔布塔摩尔的抗咳作用不仅仅是由支气管扩张介导的.
- 研究结果表明,萨尔布塔摩尔可能对咳反射有直接的神经抑制作用.
相关概念视频
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
205
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
205
01:20Asthma: Pathogenesis and Management
293
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
293
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
195
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
195
01:24Antiasthma Drugs: Methylxanthines
151
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
151
01:17Drugs Used in Lower Respiratory Disorders: Overview
320
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
320
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
182
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
182