一个急性大动脉解剖预后得分,用于预测急性胸前大动脉解剖的早期住院死亡率
Satoshi Kimura1,2, Hiroaki Sato3, Shohei Shimajiri2
1Department of Clinical Pathology, Kitakyushu City Yahata Hospital, Kitakyushu, Japan.
概括
使用常规实验室测试的新预后得分可能有助于预测急性胸前大动脉剖析 (ATAD) 患者的早期死亡率. 这一分数结合了D-二聚体,BNP,AST和LD水平,为评估ATAD预后提供了一个简单的工具.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 医学诊断 医学诊断 医学诊断
背景情况:
- 急性胸前大动脉解剖 (ATAD) 是一种危及生命的疾病,死亡率高.
- 环境,遗传和传染因素有助于ATAD.
- 单细胞/巨细胞的存在和特定的实验室标记物与ATAD预后有关.
研究的目的:
- 调查常规实验室数据与ATAD患者的预后之间的关系.
- 评估D-二聚体,BNP,AST和LD水平的实用性,以及单细胞比率,用于预测ATAD结果.
- 为早期ATAD风险评估开发一个简单的预后得分.
主要方法:
- 一个单一中心的回顾性研究分析了118名ATAD患者 (59例早期死亡,59例幸存者).
- 统计调查早期死亡率与实验室数据之间的关联.
- 基于D-二次体,BNP,AST和LD水平的急性大动脉解剖预后得分 (AAD-PS) 的发展.
主要成果:
- 在患有早期死亡率的患者中观察到升高的AST/LD,D-二次和BNP水平.
- 降低周围血液单细胞比率与过早死亡有关.
- 与心脏热素I相关的AST/LD比率是最重要的预测指标;AAD-PS显示AUC为0.895.
结论:
- 开发的AAD-PS,利用常见的实验室测试,显示出作为预测ATAD预后的新工具的潜力.
- 这一分数为ATAD患者早期风险分层提供了一种实用方法.
- 需要在更大的队列中进一步验证AAD-PS.
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