在患有鼻癌的患者中,辐射诱导的白质功能障碍
Xingyou Zheng1, Li Li2, Jian-Ming Gao3
1Department of Medical Imaging, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China.
Frontiers in neuroscience
|March 25, 2025
概括
鼻癌 (NPC) 的放射治疗减少了白质 (WM) 的功能连接性. 放射治疗后的患者显示WM-to-WM和WM-to-灰质连接性下降,影响视觉和运动系统.
科学领域:
- 神经成像是一种神经成像.
- 放射治疗对放射疗法的影响
- 在瘤学瘤学.
背景情况:
- 在鼻癌 (NPC) 放射治疗 (RT) 后,已知存在结构白质 (WM) 异常.
- 在NPC的RT之后,WM的功能性改变仍未得到充分研究.
研究的目的:
- 通过使用功能连接强度 (FCS) 来研究辐射诱导的WM功能变化.
- 为了比较前-RT和后-RTNPC患者之间的WM功能连接.
主要方法:
- 对111名NPC患者进行了功能连接强度 (FCS) 分析 (47名RT前,64名RT后).
- 评估了白物质到白物质 (WW-FCS) 和白物质到灰物质 (GW-FCS).
- 在后RT组中,研究了GW-FCS和辐射剂量之间的相关性.
主要成果:
- 与RT前患者相比,RT后患者在左上大脑,内囊右前肢,双侧后丘脑辐射和左壁膜中呈现WW-FCS降低.
- 与RT前患者相比,RT后患者在左尾状,双边视觉皮层和右腹前额皮层的GW-FCS下降.
- 在后RT组中,视觉皮层GW-FCS的减少与向大脑干和左叶的辐射剂量负相关.
结论:
- 对NPC的放射治疗导致WM的功能连接性降低.
- 观察到的WW-FCS和GW-FCS的减少表明视觉和运动系统的潜在功能障碍.
- 结果突出了RT对NPC患者大脑连接的影响.
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