相关实验视频
Updated: May 20, 2025

10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
2.3K
非编码RNA:在癌症和炎症性疾病中新兴的生物标志物和治疗点
Basma Hossam Abdelmonem1,2, Lereen T Kamal1, Lilian Waheed Wardy3,4
1Institute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.
Frontiers in oncology
|March 25, 2025
概括
非编码RNAs (ncRNAs) 是基因表达的关键调节者,影响癌症和炎症疾病. 研究强调了它们作为个性化医学和诊断的生物标志物和治疗点的潜力.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 生物化学 生化学
背景情况:
- 非编码RNAs (ncRNAs) 在转录,后转录和表观遗传层面调节基因表达.
- 异常的ncRNA表达与癌症进展,转移和治疗反应有关.
- ncRNA与关键细胞通路 (MAPK,Wnt,PI3K/AKT/mTOR) 相互作用,影响增殖,亡和免疫反应.
研究的目的:
- 审查ncRNAs作为癌症和炎症疾病中的生物标记物和治疗点的作用.
- 探索基因调节中的ncRNA机制及其诊断/治疗影响.
- 评估基于ncRNA的诊断和向治疗的潜力.
主要方法:
- 在PubMed和谷歌学者 (2014-2025) 的综合文献综述.
- 包括关于ncRNA在癌症和炎症疾病中的作用的同行评审研究.
- 排除非英语,非同行评审和不确定的研究.
主要成果:
- ncRNAs (microRNAs,长非编码RNAs,圆形RNAs) 对于基因调节至关重要.
- ncRNA表达模式为非侵入性诊断和向治疗提供了潜力.
- 基于RNA的疗法 (抗miRNA,miRNA模仿) 是有前途的,目前正在进行开发,以应对稳定性和传递挑战.
结论:
- ncRNAs代表了癌症和炎症疾病的重要生物标志物和治疗点.
- 精准医学的进步利用ncRNA分析来实现个性化治疗和改善患者的治疗结果.
- 对ncRNA传递和稳定性的进一步研究对于临床翻译至关重要.
相关概念视频
lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
MicroRNAs
21.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
Types of RNA
62.9K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
62.9K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Non-Canonical Wnt Signaling Pathways
7.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.2K
Experimental RNAi
6.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.0K

