酒精性肝病的分子调节剂:对微RNA和长非编码RNA的全面分析
Lin Zhang1, Rongqi Wang1, Yuemin Nan1
1Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Frontiers in medicine
|March 25, 2025
概括
非编码RNAs,包括长非编码RNAs (lncRNAs) 和microRNAs (miRNAs),是酒精性肝病 (ALD) 发展的关键参与者. 了解这些分子为ALD提供了新的诊断和治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 酒精性肝病 (ALD) 的发病过程涉及复杂的生物分子路径.
- 目前对ALD分子机制的理解尚不完整,缺乏有效的治疗方法.
- 非编码RNAs,特别是lncRNAs和miRNAs,与ALD的发展有关.
研究的目的:
- 审查lncRNAs和miRNAs在ALD中的作用和机制.
- 探索lncRNAs和miRNAs作为ALD的诊断标记物和治疗点的潜力.
主要方法:
- 对ALD中非编码RNA研究的文献综述.
- 分析miRNA在ALD病原性 (炎症,氧化应激,脂质代谢,亡,纤维化) 中的调节作用.
- 检查肝损伤和修复中的lncRNA与miRNA相互作用.
主要成果:
- 微RNAs,特别是miR-155,miR-223和miR-34a,对关键的ALD过程进行关键调节.
- lncRNAs通过涉及miRNAs的复杂调节网络中的相互作用来调节肝损伤和修复.
- 这些非编码RNA是ALD背后的分子机制的组成部分.
结论:
- 非编码RNA在ALD病变发生过程中至关重要.
- lncRNAs和miRNAs为新型ALD诊断标记提供了有希望的途径.
- 向lncRNAs和miRNAs可能会导致ALD的有效治疗策略.
相关概念视频
lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Cell Specific Gene Expression
13.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.3K
Types of RNA
62.9K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
62.9K
Regulation of Expression Occurs at Multiple Steps
22.1K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
22.1K
Regulation of Expression at Multiple Steps
857
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
857


