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Updated: May 20, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
系统性炎症和CKD总指数之间的关联:来自NHANES 1999-2018年的证据
1Department of Nephrology, Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Chongqing, China.
系统性炎症总指数 (AISI) 与慢性病 (CKD) 有关. 更高的AISI水平,特别是超过181.27,表明与CKD患病率有更强的关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 炎症研究 炎症研究
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 影响着人口的很大一部分,确定可靠的生物标志物对其早期检测至关重要.
- 系统性炎症在各种慢性疾病的发病过程中起作用,包括CKD.
- 系统性炎症总指数 (AISI) 是一个复合标记,反映了整体炎症状况.
研究的目的:
- 调查系统性炎症总指数 (AISI) 与慢性病 (CKD) 患病率之间的关联.
- 与其他炎症标志物相比,评估AISI在识别CKD和低估计的膜过率 (eGFR) 的有效性.
主要方法:
- 从1999年到2018年进行的国家健康和营养检查调查 (NHANES) 的数据分析.
- 根據eGFR<60mL/min/1.73m2或白色素尿 (ACR ≥30 mg/g) 定義的CKD.
- 使用多变量回归,平滑曲线拟合,子组分析和ROC曲线分析. AISI进行了日志转换 (Ln-AISI).
主要成果:
- 在Ln-AISI和CKD (OR = 1.24) 和低eGFR (OR = 1.17) 之间发现了积极的关联.
- 平滑曲线的拟合证实了AISI和CKD/低eGFR之间的积极关系.
- 当AISI超过181.27.27时,这种关联更加明显.
- 与LYM,SII,PLR和PPN相比,AISI在识别CKD和低eGFR方面表现出更好的区别和准确性.
结论:
- AISI与CKD患病率有显著和积极的相关性.
- AISI和CKD之间的关联在AISI水平大于181.27.7时更为强烈.
- 与其他常见的炎症标志物相比,AISI是识别CKD的更有效的指标.
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