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农村,心血管风险因素和儿童,青少年和年轻成人癌症幸存者的早期心血管疾病
David H Noyd1,2, Anna Bailey3, Amanda Janitz3
1Ben Towne Center for Childhood Cancer and Blood Disorders Research and the Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
Journal of adolescent and young adult oncology
|March 25, 2025
概括
心血管风险因素 (CVRFs) 在癌症幸存者中没有预测早期心血管疾病 (CVD). 然而,来自农村地区的幸存者患心血管疾病的风险更高.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 由于心脏毒性治疗,心血管疾病 (CVD) 对癌症幸存者来说是一个重大问题.
- 众所周知,心血管风险因素 (CVRF) 会在晚年加强心血管疾病风险.
- 在癌症幸存者中,基线CVRFs和早期心血管疾病之间的关联需要进一步调查.
研究的目的:
- 评估基线心血管风险因素 (CVRFs) 与心血管疾病 (CVD) 在年轻癌症患者早期生存期的相关性.
- 评估使用信息学方法来识别癌症幸存者的CVRF的可行性.
主要方法:
- 对731名癌症幸存者 (诊断时0-29岁) 的分析,诊断时间为2010-2017年.
- 在诊断后1年内从电子健康记录中提取CVRF (高血压,糖尿病,脂质失调,肥胖症).
- 统计分析以确定CVRFs,保险状况,地理位置 (农村与城市) 和CVD发病率在诊断后1-5年之间的关联.
主要成果:
- 1.4%的幸存者在诊断后1-5年内发展出心血管疾病.
- 公共医疗保险和晚期影响风险层与心血管疾病有积极的关联.
- 农村地区的幸存者患心血管疾病的风险是城市幸存者的4.1倍,即使在调整后.
结论:
- 在癌症幸存者中识别CVRF是可行的信息学方法.
- 基线CVRFs在早期生存期没有与心血管疾病相关.
- 居住在农村地区的幸存者面临患心血管疾病的风险明显更高.
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