高覆盖度的代谢学揭示了与肠道微生物群相关的2型糖尿病的血清代谢特征
Wangshu Qin1,2, Sijia Zheng1,2,3, Lina Zhou1,2
1CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Journal of proteome research
|March 25, 2025
概括
肠道微生物组的代谢变化与2型糖尿病 (T2D) 有关. 这项研究确定了关键的改变代谢物和T2D查的生物标志物小组,提供了新的诊断和治疗见解.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 人类疾病的发病因子人类疾病的发病因子
背景情况:
- 肠道微生物组的代谢变化与2型糖尿病 (T2D) 病原发生有关.
- 对这些全球代谢变化及其在T2D中的功能作用的全面理解是有限的.
研究的目的:
- 进行从有和没有T2D的个体的血清样本中进行高覆盖度的代谢学分析.
- 为了确定特定的微生物群相关化合物和在T2D中改变的代谢途径.
- 定义和验证用于T2D查的微生物群依赖生物标志物小组,并阐明特定微生物产品在T2D进展中的功能作用.
主要方法:
- 来自1282名中国人的血清样本 (有或没有T2D) 的高覆盖度代谢学概况.
- 分析了220个检测到的与微生物群相关的化合物,确定了111个显著改变的化合物.
- 路径丰富,相关性分析,生物标志物面板定义和验证以及N-乙组合胺的功能测试.
主要成果:
- 在检测到的220种微生物组相关化合物中,有111种在T2D中发生显著变化,形成了一个交互式调节网络.
- 已发现的异常代谢途径包括胺代谢,不和脂肪酸生物合成和氨基酸代谢 (Tryptophan,Lysin,分支链氨基酸).
- 一个经过验证的生物标志物小组 (pipecolinic acid, methoxysalicylic acid,N-acetylhistamine,3-hydroxybutyrylcarnitine) 显示T2D查的敏感性超过78%. 发现N-乙基组胺抑制AMPK酸化,影响T2D进展.
结论:
- 由肠道微生物群驱动的代谢失调在T2D中起着重要作用.
- 鉴定的代谢变化和生物标志物小组为改善T2D诊断和查提供了潜力.
- 监测这些特定的代谢变化可能有助于未来的T2D诊断和治疗策略.
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