血清细胞因子及其可溶性受体在训练有素和未训练有素的男性之间在强烈的耐力运动后受到不同的调节
Jeremy B Ducharme1, Jonathan W Specht1, Alyssa R Bailly1
1Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, New Mexico, United States.
概括
耐力训练可以减轻男性的运动引起的炎症. 训练有素的个体表现出减少的促炎性细胞因子和增加的可溶性细胞因子受体,导致细胞因子的生物利用率较低,与未经训练的男性相比.
科学领域:
- 运动免疫学 运动免疫学
- 炎症和细胞因子
- 耐力训练的调整 耐力训练的调整
背景情况:
- 耐力训练调节免疫系统,促进抗炎作用.
- 细胞因子及其受体在运动反应中至关重要,但它们的并行变化还未得到充分研究.
- 可溶性细胞因子受体可以抑制细胞因子信号传递,影响生物可用性.
研究的目的:
- 研究强烈运动对受训与未受训男性血清细胞因子和可溶性细胞因子受体的影响.
- 探索运动诱导的抗炎适应背后的机制.
- 为了比较高强度循环后的细胞因子和可溶性受体概况.
主要方法:
- 血清样本从耐力训练和未训练的男性收集,在他们的呼吸补偿点骑自行车1小时后.
- 测量了促炎性细胞因子 (IL-6,TNF-α,IL-1β,CCL2,VEGFA) 和抗炎性细胞因子 (IL-10,IL-1Ra).
- 评估了可溶性细胞因子受体 (sIL-1RII,sGP130,sTNFRI,sTNFRII,sVEGFR1,sVEGFR2) 的表达.
主要成果:
- 未经训练的男性在运动后表现出增加的促炎细胞因子和减少的抗炎细胞因子.
- 受过训练的男性保持稳定的促炎细胞因子水平,并增加了抗炎细胞因子.
- 训练有素的男性表现出可溶性细胞因子受体的增加,这表明细胞因子的生物可用性降低了,而未经训练的男性显示没有变化或减少.
结论:
- 耐力训练会诱导一种抗炎性适应,其特征是对运动的细胞因子反应减弱.
- 在训练有素的个体中,可溶性细胞因子受体的增加可能会导致细胞因子的生物可用性和炎症降低.
- 这些发现突显出一种新的免疫适应耐力运动的免疫机制.
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