通过增强反应性氧物种和耗尽谷氨来增强强大的声动力学癌症疗法
Nannan Zheng1, Dan Li1, Xin Hu1
1College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, 518118, P. R. China.
Nano letters
|March 25, 2025
概括
铁原子分散纳米粒子 (Fe-N-C) 克服了瘤微环境的局限性,用于增强的声动疗法 (SDT). 这些纳米颗粒产生反应性氧物种 (ROS) 并耗尽谷,诱导癌细胞死亡.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 瘤微环境 (TME) 对像声动疗 (SDT) 这样的基于活性氧物种 (ROS) 的疗法提出了重大挑战.
- 克服TME的局限性对于提高癌症治疗的疗效至关重要.
研究的目的:
- 开发新的声敏剂,可以有效地产生ROS,并克服在SDT中与TME相关的挑战.
- 研究铁原子分散纳米颗粒 (Fe-N-C) 作为有效的声敏剂的潜力.
主要方法:
- 铁原子分散纳米粒子 (Fe-N-C) 的合成和表征.
- 评估Fe-N-C的声敏化能力,包括ROS生成和类似酶的活动 (过氧化酶,催化酶,谷氨氧化酶).
- 密度函数理论 (DFT) 计算以阐明ROS生成机制.
- 瘤特异性和治疗疗效的评估 in vitro 和 in vivo.
主要成果:
- 在声动力学条件下,Fe-N-C纳米颗粒证明了高效的ROS生成.
- 这些纳米颗粒表现出类似过氧化酶的活性,可催化H2O2转化为有毒的基基 (·OH) 和类似催化酶的活性,产生O2.
- Fe-N-C的类似谷氨氧化酶的活性耗尽了谷氨 (GSH),诱导瘤细胞亡和铁亡.
- DFT的计算揭示了一种机制,涉及到由声电子激活O2和随后的OH形成.
- 在SDT中Fe-N-C显示出优异的瘤特异性.
结论:
- 原子分散的铁纳米粒子 (Fe-N-C) 是有效的声敏化剂,可以克服TME的限制,从而提高SDT.
- Fe-N-C的多酶类活动和ROS生成有助于强大的抗瘤作用,包括亡和铁亡.
- 开发的Fe-N-C纳米粒子通过声动力学方法为向癌症治疗提供了一个有前途的战略.
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