CYP2D6表型对固性,不良反应和对阿里皮普拉和瑞斯佩里使用者的态度的影响
Elina Hietala1,2,3, Anssi Solismaa1,4, Markku Lähteenvuo5
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Acta neuropsychiatrica
|March 25, 2025
概括
超快速的cytochrome P450 2D6 (CYP2D6) 酶活性与更多的不良影响和对aripiprazole的负面态度有关,但不与risperidone有关. 这种遗传变异会影响精神病患者的抗精神病治疗经验.
科学领域:
- 药物基因组学 药物基因组学
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 药物不服药和负面态度在治疗精神疾病方面构成挑战.
- 细胞染色体P450 2D6 (CYP2D6) 代谢阿里皮普拉和RISPERIDONE,其中的遗传变异可能会影响治疗结果.
- 对于CYP2D6变异对坚持和药物治疗态度的具体影响尚不清楚.
研究的目的:
- 研究CYP2D6表型,药物坚持,不良反应和阿里皮普拉和RISPERIDONE使用者的态度之间的关系.
- 为了确定CYP2D6遗传变异是否会影响精神病患者的治疗经验.
主要方法:
- 分析来自SUPER-芬兰队列的数据 (10,474名成年人患有精神病发作).
- 包括1,429名阿里皮普拉和828名RISPERIDONE使用者.
- 使用对神经乱治疗态度 (ANT) 问卷评估了坚持和不良影响;在一个子组 (n=1,000) 中检查了态度.
- 使用后勤和β回归分析来检查CYP2D6表型和结果之间的关联.
主要成果:
- 没有发现CYP2D6表型与RISPERIDONE使用者的坚持,不良反应或态度之间的关联.
- 在阿里皮普拉使用者中,没有观察到CYP2D6表型与坚持之间的联系.
- 具有超快速CYP2D6表型的阿里皮普拉使用者报告了更多的不良反应 (OR = 1.71) 和对抗精神病治疗的不太有利态度 (β = −0.48).
结论:
- 超快速的CYP2D6表型与aripiprazole使用者的不良反应增加和对抗精神病药物的负面态度有关.
- CYP2D6表型似乎不会影响RISPERIDONE使用者的坚持,不良反应或态度.
- 这些发现突出了对阿里皮普拉治疗经验的潜在药物遗传影响.
相关概念视频
Antipsychotic Drugs: Typical and Atypical Agents
144
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
144
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
53
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
53
Drug Therapy
32
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
32
Factors Affecting Drug Response: Overview
1.8K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.8K
Psychosis and Antipsychotic Drugs: Overview
165
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
165
Psychological and Sociocultural Causes of Schizophrenia
40
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
40


