精神分裂症中的微生物组-肠-大脑概况及其与认知表现的潜在联系:从病例对照研究中得出的发现
Hui Wu1,2,3, Xu Jiawei1, Zhi Wen2
1Radiology Department, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Schizophrenia bulletin
|March 25, 2025
概括
精神分裂症 (SZ) 涉及肠道微生物组的变化,影响大脑结构和认知. 像Proteus这样的特定细菌可能会损害认知功能,强调需要考虑抗精神病治疗效果.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 微生物组-肠-大脑轴越来越多地与精神分裂症 (SZ) 有关.
- 有限的研究探讨了肠道微生物组,大脑变化和SZ的临床症状之间的相互作用.
- 长期抗精神病治疗对这一轴的影响仍未得到充分研究.
研究的目的:
- 研究肠道微生物组组成,大脑结构和功能,以及SZ患者的临床表现之间的关系.
- 探索抗精神病治疗对SZ中微生物群-肠-大脑轴的影响.
- 确定与SZ认知缺陷相关的特定微生物特征.
主要方法:
- 招募了171名参与者:27名未使用过药物的第一期SZ (FSZ),72名长期治疗的SZ (CSZ) 和72名健康对照 (HC).
- 收集的多omics数据:便16SrRNA测序,结构和功能大脑成像.
- 评估精神病症状,认知功能,并分析相关性和调解效应.
主要成果:
- 在SZ中确定了不同的微生物概况:与HC相比,Blautia减少,Proteus和Arthrobacter增加.
- 观察到与改变胆酸生物合成和脂质代谢相关的微生物失调.
- 发现关键微生物,大脑变化 (灰质体积,区域均性) 和认知表现之间的三方联系,Proteus对认知产生负面影响.
结论:
- 这项研究阐明了SZ中的微生物组-肠-大脑障碍,有助于理解认知障碍.
- 结果强调了抗精神病药物暴露在SZ微生物组-肠-大脑轴研究中的重要性.
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