长期暴露于与交通有关的空气污染和噪音以及青少年时期的动态大脑连接
Mónica López-Vicente1,2,3,4, Michelle Kusters1,2,4, Anne-Claire Binter1,2
1ISGlobal, Barcelona, Spain.
Environmental health perspectives
|March 25, 2025
概括
怀孕和童年期间的交通污染和噪音暴露与青少年大脑连接的改变有关. 这些环境因素可能会随着时间的推移影响大脑网络组织.
科学领域:
- 环境健康科学 环境健康科学
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
背景情况:
- 与空气污染和噪音等交通相关的暴露与年轻人的长期大脑变化有关.
- 以前的研究主要使用静态静止状态功能磁共振成像 (rs-fMRI) 来评估大脑连接.
研究的目的:
- 调查交通空气污染和噪音暴露以及青少年大脑功能连接之间的长期关联.
- 利用 rs-fMRI 的动态方法,捕捉时间变化的连接模式.
主要方法:
- 利用了来自R世代出生队伍的数据,评估了14种空气污染物和交通噪音.
- 在10岁和14岁时收集了rs-fMRI数据,应用k-means集群来识别五个动态连接状态.
- 采用混合效应模型来分析暴露和在每个连接状态中花费的时间之间的关联.
主要成果:
- 对氧化,颗粒物 (PM) 和道路交通噪音的暴露与在特定的大脑连接状态中度过的时间变化相关.
- 较高的产前PM暴露和儿童噪音暴露与在高连接性特征的默认模式网络状态中的时间增加有关.
结论:
- 与交通有关的环境暴露可能导致青少年大脑功能网络组织的长期变化.
- 需要进一步的研究,以了解这些连接性变化对认知和精神病理学的影响.
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