帕金森病发病率的全球趋势和预测:使用GBD 2021数据的30年分析
Libo Xu1, Zhenhao Wang1, Qingsong Li2
1The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Journal of neurology
|March 25, 2025
概括
帕金森病 (PD) 病例在全球显著增加,这是由于人口老龄化所致. 预测显示持续增加,特别是在中等收入地区和男性中,需要有针对性的卫生政策.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 帕金森病 (PD) 是一种进展性神经退行性疾病,影响运动和非运动功能.
- 全球人口老龄化,导致PD发病率预期增加.
- 了解目前和未来的PD负担对于公共卫生规划至关重要.
研究的目的:
- 使用2021年全球疾病负担 (GBD) 数据分析帕金森病的全球负担.
- 根据地区,性别和年龄,从1992年到2021年检查PD趋势.
- 预测到2030年帕金森病的未来负担.
主要方法:
- 对PD发病率和死亡率的GBD 2021数据 (1992-2021) 的分析.
- 利用年龄周期队列 (APC) 和贝叶斯年龄周期队列 (BAPC) 模型进行趋势分析和未来预测.
- 按社会人口统计指数 (SDI) 地区,性别和年龄组分的分层数据.
主要成果:
- 全球PD病例从1992年的45万例上升到2021年的134万例,年龄标准化发病率 (ASIR) 每年增加.
- 在所有SDI地区,PD负担增加,中等和高中等SDI地区的显着上升,男性的发病率更高.
- 60岁以上的个人,特别是85岁以上的个人,发生率显著增加,预计到2030年将有193万例病例.
结论:
- 显而易见的是,PD负担在全球持续增加,尤其影响中高收入地区和男性.
- 低SDI地区的PD负担可能被低估,因为医疗保健和诊断限制.
- 迫切需要针对老年人,特别是男性的健康政策,以及有效的预防和干预策略.
相关概念视频
Parkinson's Disease: Overview
399
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
399
Parkinson's Disease: Treatment
166
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
166
Neural Regulation
39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K
EPS and iPS Cells in Disease Research
2.7K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.7K
Genome-wide Association Studies-GWAS
12.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.2K


