关于低水平激光疗法的分子机制的审查:基因表达和信号通路
Reyhaneh Tamimi1, Soheila Zamanlui Benisi2,3, Mahdi Eskandarian Boroujeni4
1Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Lasers in medical science
|March 25, 2025
概括
低水平激光疗法 (LLLT) 通过改变基因表达和信号通路来影响细胞过程. 不同波长的LLLT具有不同的治疗效果,强调精确的参数选择以获得最佳结果.
科学领域:
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
- 照相医疗 (photomedicine) 是一种医学.
背景情况:
- 低水平激光疗法 (LLLT) 通过向照射来调节细胞和分子功能.
- 通过基因表达和信号通路,LLLT影响关键的细胞活动,包括增殖,分化,迁移和新陈代谢.
研究的目的:
- 审查LLLT的分子机制,重点关注对基因表达和信号通路的波长特异性影响.
- 在分子水平上分析LLLT如何与包括干细胞在内的各种细胞类型相互作用.
主要方法:
- 从2003年到2024年进行了全面的文献审查.
- 搜索包括PubMed,Scopus,MEDLINE,EMBASE和谷歌学者使用关键词,如"基因表达"",信号通路"",光生物调制"和"LLLT".
- 选了150项最近的研究,重点关注那些详细描述基因表达变化和激光诱导的信号通路的研究.
主要成果:
- 随着激光参数和波长,LLLT效应会有很大的变化.
- 红色和红外激光促进细胞增殖,分化,减少炎症,增强伤口愈合.
- 蓝色激光抑制细胞增殖;绿色激光减少炎症,并有助于诸如椎间盘变性等疾病.
结论:
- LLLT的治疗结果与基因表达和激光诱导的信号通路的特定变化直接相关.
- 选择合适的激光波长和参数对于实现所需的治疗效果至关重要.
- 了解这些分子机制是优化在各种医疗条件下LLLT应用的关键.
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