在精神分裂症和重度抑郁症中作为部分共享的病理生理机制的无组织的状功能连接:一个跨诊断的fMRI研究
Yao Zhang1, Chengjia Shen1, Jiayu Zhu1
1Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Brain topography
|March 25, 2025
概括
条形状连接的减少与精神分裂症和严重抑郁症的负面症状有关. 这些发现表明,在两种疾病中,这些普遍的症状背后存在着共同的大脑机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 负面症状是精神分裂症 (SZ) 和严重抑郁症 (MDD) 的核心特征.
- 条纹功能受损与负面症状有关,但跨诊断的神经机制尚不清楚.
- 了解共享的神经基础对于开发统一的治疗策略至关重要.
研究的目的:
- 调查与SZ和MDD中负面症状相关的条纹体的共享静止状态功能连接 (rsFC) 改变.
- 在跨诊断的背景下,识别潜在的负面症状的共同和独特的神经机制.
- 探索纹状RSFC与症状严重程度之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 数据来自60名负症状患者 (33名SZ,27名MDD) 和52名健康对照 (HC).
- 使用消极症状评估尺度 (SANS) 评估消极症状的评估.
- 分析了12个条纹性子区域和整个大脑之间的rsFC.
主要成果:
- 无论是SZ还是MDD患者,在特定的骨子区域和骨/对侧骨之间,以及在背尾骨和中额头骨之间,rsFC都降低了.
- 在SZ.中,右背面面门-右白体rsFC的减少与负面症状严重程度相关.
- 与MDD患者相比,SZ患者在背上条纹体和前中心环,中环和舌环之间表现出增加的rsFC.
结论:
- 减少的氨基 rsFC 是一个共享的神经机制,有助于SZ和MDD的负面症状.
- 异常的条状功能连接可能代表这些疾病中负面症状的常见神经基质.
- 这些发现支持研究领域标准提出的部分共享机制的建议,这些机制是SZ和MDD中可比的临床特征的基础.
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