肺外结核的诊断和治疗延迟和与死亡率的关联:坦桑尼亚 Mbeya 的经验
Erlend Grønningen1,2, Marywinnie Nanyaro3, Esther Ngadaya3
1Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway.
PloS one
|March 25, 2025
概括
在这项研究中,延迟诊断和治疗肺外结核 (EPTB) 并没有显著影响死亡率. 即使是没有接受结核病治疗的患者也没有增加死亡率,这表明需要进一步的研究.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 与肺结核相比,肺外结核 (EPTB) 诊断和治疗延迟的了解很少.
- 在低收入和中等收入国家,许多EPTB病例缺乏微生物学确认,可能低估了死亡率.
- 艾滋病毒和营养不良的高患病率使得受影响地区的EPTB管理变得复杂.
研究的目的:
- 评估肺外结核 (EPTB) 患者的诊断和治疗延迟情况.
- 确定这些延迟与高艾滋病毒和营养不良流行率环境中的死亡率之间的关联.
主要方法:
- 一组106名EPTB患者在 Mbeya区域推医院从诊断到治疗完成期间进行了跟踪.
- EPTB的分类是基于临床病例定义.
- 使用非参数测试的统计分析被用来比较结果.
主要成果:
- 35% (37/106) 的EPTB患者在研究期间死亡.
- 幸存者和非幸存者之间的中位数诊断和治疗延迟是相似的.
- 值得注意的是,有21名患者没有接受结核病治疗,但这与死亡率增加或诊断延迟无关.
结论:
- 这项研究没有发现EPTB患者的诊断/治疗延迟和死亡率之间具有统计学意义的联系.
- 在一些EPTB病例中缺乏结核病治疗并没有导致较高的死亡率.
- 需要对更大的队列进行进一步的前性研究,以阐明影响EPTB延迟的因素及其对死亡率的影响.
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