Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epistaxis01:30

Epistaxis

113
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
113

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same authorSame journal

A molecular glue to take down mutant BRAF.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

Treating depression through G proteins.

Science signaling·2026
Same author

Sense and stromal density.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026

相关实验视频

Updated: May 20, 2025

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
05:44

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

20.0K

通过鼻子治疗神经炎症

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science signaling
|March 25, 2025
PubMed
概括

一种新型抗体在脑损伤后注入鼻内,促进神经保护并减少炎症. 这种鼻腔抗体输送为大脑损伤恢复提供了有前途的治疗策略.

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 脑损伤会引发有害的神经炎症反应.
  • 目前治疗脑损伤的方法存在局限性.
  • 针对神经炎症对恢复至关重要.

研究的目的:

  • 为了研究一个全身注射的抗体的神经保护和抗炎作用.
  • 为了评估脑损伤后这种抗体的鼻内输送的疗效.

主要方法:

  • 在动物中的脑损伤模型.
  • 特定抗体的鼻腔内注射.
  • 评估神经炎症标志物 (例如细胞因子).
  • 评估神经保护标志物 (例如神经元存活率).

主要成果:

  • 鼻内抗体的使用显著降低了神经炎症的关键标志物.
  • 抗体治疗导致受伤大脑区域的神经元存活率提高.
  • 通过鼻内输送方法没有观察到任何显著的不良影响.

结论:

  • 鼻内抗体输送是针对脑炎症的可行和有效途径.

更多相关视频

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

23.1K
Intranasal Administration of CNS Therapeutics to Awake Mice
07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

58.7K

相关实验视频

Last Updated: May 20, 2025

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
05:44

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

20.0K
A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

23.1K
Intranasal Administration of CNS Therapeutics to Awake Mice
07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

58.7K
  • 这种方法在脑损伤后显示出显著的神经保护潜力.
  • 对这种治疗策略的进一步研究有必要进行临床转化.