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儿童肥胖的多基因分数基于成人与儿童的总结统计数据
Danick Goulet1, Michel Boivin2, Christopher Gravel1,3,4
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Canadian journal of physiology and pharmacology
|March 25, 2025
概括
儿童体质指数 (BMI) 的多基因分数 (PGS) 非常重要,因为BMI遗传学随着年龄的增长而发生变化. 基于成人的PGS在老年儿童中显示出更强烈的BMI关联,而基于儿童的PGS在年轻儿童中更好地识别肥胖.
科学领域:
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
- 肥胖问题研究研究
背景情况:
- 身体质量指数 (BMI) 的遗传结构在整个发育过程中不断演变.
- 现有的BMI多基因分数 (PGS) 主要来自成年人群,这可能会限制它们对儿童的有用性.
- 了解儿童肥胖的遗传易感性对于有针对性的干预至关重要.
研究的目的:
- 描述儿童对肥胖的遗传易感性.
- 为了在儿科队列中比较成人与儿童BMI的PGS的表现.
- 评估这些PGS与BMI的关联以及它们在不同年龄组中区分肥胖的能力.
主要方法:
- 使用了717名4至13岁儿童的队列.
- 通过检查风险类别的平均BMI来评估成人和儿童的PGS.
- 通过逻辑回归评估肥胖的识别,并通过线性回归评估BMI z-score关联.
主要成果:
- 基于成人和儿童的PGS都显示出与BMI和肥胖风险的显著关联.
- 基于成人的PGS显示,与基于儿童的PGS (β = 0.21-0.30) 相比,BMI z-score (β = 0.24-0.39) 的增加更大.
- 对于4-7岁的儿童,基于儿童的PGS比基于成人的PGS (OR = 1.74-2.06) 的肥胖率更高 (OR = 1.75-2.33). 相反,对于8-13岁的成年人,基于PGS的几率比较高 (OR = 1.78-2.54),而不是基于儿童的PGS (OR = 1.56-1.79).
结论:
- 基于成人和儿童的PGS在确定儿童肥胖风险方面是有效的.
- 基于成人PGS的BMI的预测性能强化并超过了8岁及以上儿童的基于儿童的PGS.
- 建议针对特定年龄的PGS开发或验证,以获得最佳的儿科肥胖预测.
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