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Updated: May 20, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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精确调节蛋白质降解的策略

Shipeng He1, Guoqiang Dong2, Chunquan Sheng2

  • 1Institute of Translational Medicine, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China.

Accounts of chemical research
|March 25, 2025
PubMed
概括

使用向蛋白解的仿真体 (PROTACs) 的向蛋白降解 (TPD) 与抑制剂相比具有优势. 智能 PROTAC 设计的创新增强了特异性和控制,解决了精准医学临床翻译的挑战.

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