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Updated: May 13, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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为具有病理生理学意义的3Din-vitroIBD疾病模型制造多层异质细胞组件,用于高吞吐量药物查

Mamta Kumari1, Kamare Alam2, Santanu Kaity1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, West Bengal 700054, India.

Biofabrication
|March 25, 2025
PubMed
概括

开发先进的体外肠道模型,如3D有机体,对于预测口服药物的生物可用性和改善药物发现至关重要. 这些模型比传统方法提供了更好的人类肠上皮细胞 (hIEC) 代表性.

关键词:
3D体外疾病模型 3D体外疾病模型三维脚手架的3D脚手架.吸收药物吸收药物吸收药物开发是药物的发展.肠道的通透性 肠道的通透性组织工程是组织工程.

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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...