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一个基于闪光器单体环形 (AnnPET) 的临床前PET扫描仪:构造和NU4-2008性能测试

Raymond R Raylman¹, Alexander V Stolin¹, Gangadhar Jaliparthi¹

¹Center for Advanced Imaging, Department of Radiology, One Medical Center Dr, Box 9236, West Virginia University, Morgantown, WV 26506, United States of America.

Physics in medicine and biology

|March 25, 2025

概括

一种新的临床前正子发射断层扫描 (PET) 扫描仪,AnnPET,利用单体闪光器和神经网络. 它表现出有前途的性能,包括高分辨率和灵敏度,用于先进的临床前研究.

科学领域:

医疗成像医学成像
核医学是一种核医学.
仪器化仪器化仪器化

背景情况:

传统的临床前正子发射断层扫描 (PET) 扫描仪使用离散的闪器阵列或连续块.
新型探测器设计对于推进临床前研究能力至关重要.
单立体闪器设计在PET扫描仪结构中提供了潜在的优势.

研究的目的:

开发和评估一个新的临床前PET扫描仪,AnnPET,基于一个单体闪器.
通过使用已建立的NEMA NU4-2008协议来评估AnnPET的性能.
研究深度残留卷积神经网络用于事件定位的应用.

主要方法:

使用十四面伊正酸盐单立方环的AnnPET扫描仪的构造.
在介电流体浸泡系统中整合了冷却和温度稳定的多像素光子计数器.
利用深度剩余卷积神经网络来准确地定位闪电器内的事件.

主要成果:

实现了高空间分辨率,全宽半最大值 (FWHM) 值低至1.38mm.
展示了9.5%的峰值检测灵敏度和234kcps的峰值噪声等效计数速率在14.4MBq.
根据NEMA NU4-2008的绩效评估,该新型设计显示出有希望的结果.

结论:

作为一种临床前PET扫描仪,AnnPET系统显示出显著的前景.
单体闪光灯结合基于神经网络的定位提供了出色的性能.
基于这些令人鼓舞的结果,AnnPET系统的进一步发展是合理的.

关键词:

一个单一的闪器.定子发射断层扫描 (PET).在临床前的临床前的临床前.

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