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伊索尼亚齐德 (INH) 是一种结核病药物检测方法,在真实样本中使用关闭式光[Ce (o-Van) ₃ (H₂O) ₃]探针

Rajpal¹, Subhajit Jana¹, Ravi Prakash Ojha¹

¹School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|March 25, 2025

概括

开发了一种新的光传感器,用于监测异化 (INH) 药物水平. 这种传感器在生物样本中准确检测INH,有助于安全治疗结核病.

科学领域:

分析化学分析化学
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

伊索尼亚 (INH) 是结核病 (TB) 治疗的关键抗生素.
精确的INH度监测至关重要,因为不适当的剂量可能会产生严重的副作用.
现有的方法可能需要改进,以实现常规的临床应用.

研究的目的:

合成和描述一种用于选择性异化物检测的新型光传感器.
建立一种敏感且可靠的方法,用于在各种矩阵中量化INH.
开发一种工具,以改善结核病治疗期间的患者监测.

主要方法:

通过沉合成一种 (III) - 骨 - 瓦尼林协调复合物[Ce (o-Van) 3 (H2O) 3],通过沉.
使用HRMS,FT-IR,UV-Vis,XPS,XRD,SEM和TGA进行全面的表征.
基于INH诱导的光火的"关闭"光试验的开发.

主要成果:

合成的复合物作为选择性光传感器对异化起作用.
在14.47μM - 147.966μM (R2 = 0.994) 的度范围内观察到线性光反应.
在INH中达到1.63μM的低检测极限 (LOD).
在药物片,人体尿液和血液样本中成功检测到INH.

结论:

开发的[Ce(o-Van) 3(H2O) 3复合体是一种有效的光探针,用于异化.
该传感器为INH量化提供了一种敏感,选择性和可靠的方法.
这种方法对结核病管理中的治疗药物监测具有前景.

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