在欧洲成年人中暴露于多环芳 (PAH):来自HBM4EU一致研究的证据
Achilleas Karakoltzidis1, Nafsika Papaioannou1, Catherine Gabriel1
1Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, University Campus, Thessaloniki 54124, Greece; HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Balkan Center, Bldg. B, 10th km Thessaloniki-Thermi Road, 57001, Greece.
Environment international
|March 25, 2025
概括
欧洲成年人对多环芳 (PAH) 暴露的程度各不相同,吸烟者和妇女的暴露水平更高. 诸如国家,城市化和教育等因素影响PAH代谢物度,为公共卫生战略提供信息.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物监测 生物监测
背景情况:
- 多环芳 (PAHs) 是持久性环境污染物,与有害健康影响有关.
- 由于暴露于PAH,欧洲人口面临着重大的公共卫生挑战.
- 了解人类暴露需要协调,大规模的生物监测研究.
研究的目的:
- 在一个协调的欧洲成年人队列中评估人类对13种尿路PAH代谢物的暴露.
- 为了在不同欧洲地区实现对PAH暴露的统一理解.
- 确定影响20-39岁成年人PAH暴露的关键因素.
主要方法:
- 在20-39岁的欧洲成年人队列中对13种尿液PAH代谢物的协调评估.
- 在多个欧洲实验室进行严格的参与者选择和标准化生物标志物分析.
- 多变量线性回归用于识别暴露因子和共变量.
主要成果:
- 与非吸烟者相比,吸烟者表现出持续升高的PAH代谢物水平,其中甲代谢物占主导地位.
- 波兰的纳夫他林代谢物度最高;卢森堡的皮林代谢物度较高.
- 在城市环境中,女性和受教育程度较低的人群中观察到更高的PAH水平.
结论:
- 协调生物监测有效地揭示了人口层面的PAH暴露模式和影响因素.
- 调查结果为评估欧盟委员会关于可持续性化学品战略提供了基准.
- 有针对性的公共卫生干预可以通过了解人口统计和生活方式对PAH暴露的影响来获取信息.
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