前列腺癌患者的性功能障碍根据疾病阶段和治疗方式
W Kinnaird1, P Schartau2, M Kirby3
1University College London, Gower Street, WC1E 6BT, London, UK; University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK.
Clinical oncology (Royal College of Radiologists (Great Britain))
|March 25, 2025
概括
前列腺癌 (PCa) 治疗在98%以上的患者中引起广泛的性功能障碍 (SD),影响身体和心理健康. 先进的疾病和组合疗法加剧了这些影响,凸显了全面康复的需要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 性医学性医学性医学性医学
背景情况:
- 前列腺癌 (PCa) 的诊断和治疗显著影响患者的生活质量.
- 性功能障碍 (SD) 是一种普遍而令人痛苦的副作用,影响身体和心理领域.
- 了解SD在不同疾病阶段和治疗方法中的细微差别对于患者护理至关重要.
研究的目的:
- 调查前列腺癌 (PCa) 患者身体和心理性功能障碍 (SD) 的患病率和特征.
- 分析疾病阶段和治疗方式如何影响性副作用的体验.
- 确定与性康复相关的患者支持需求.
主要方法:
- 对654名PCa患者进行了在线调查,评估了13个领域的性副作用,性功能的重要性和支持需求.
- 收集了关于疾病阶段 (局部,局部发达,高级) 和治疗 (根性前列腺切除术,放射治疗,雄激素剥夺疗法) 的数据.
- 描述性统计和千二测试用于数据分析.
主要成果:
- 超过98%的PCa患者在治疗后报告了新的性问题.
- 常见的身体功能障碍包括勃起功能障碍 (91.0%),射精障碍 (82.9%) 和阴茎解剖变化 (70.0%).
- 心理性功能障碍很普遍,性自信的丧失 (76.2%),性欲的丧失 (67.1%) 和自尊的丧失 (57.1%) 是最常见的. 晚期疾病和组合疗法 (RP,RT,ADT) 与较高的SD率有关.
结论:
- 性功能障碍是PCa治疗的常见,严重和痛苦的后果,患者高度重视性恢复.
- 晚期PCa患者和接受组合疗法,特别是永久ADT的患者,经历最严重的SD,包括显著的性心理问题.
- 针对广泛性副作用的整体康复策略对于所有PCa幸存者至关重要,特别是那些长期使用ADT的人.
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