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Updated: May 20, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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抑制CCR1可使多发性骨髓瘤细胞对葡萄糖皮质体治疗产生敏感性

Bert Luyckx1, Maaike Van Trimpont2, Fien Declerck3

  • 1VIB-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, Gent 9052, Belgium; Department of Biomolecular Medicine, Ghent University, Corneel Heymanslaan 10, Gent 9000, Belgium; Cancer Research Institute Ghent (CRIG), Corneel Heymanslaan 10, Gent 9000, Belgium.

Pharmacological research
|March 25, 2025
PubMed
概括

这项研究揭示,阻断化学因受体CCR1可以提高多发性骨髓瘤 (MM) 中的葡萄糖皮质体 (GC) 疗效. 向CCR1可以克服MM患者的GC耐药性.

关键词:
化学因子受体是化学因子受体.葡萄糖皮质类药物耐药性 葡萄糖皮质类药物耐药性葡萄糖皮质类药物是什么多发性骨髓瘤是一种多发性骨髓瘤.

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