流行病学和分子类型的登革热病毒循环在乔哈特区,阿萨姆,印度,印度
Barbi Gogoi1, Pinkee Phukon1, Sima Kumari Dutta1
1Viral Research Diagnostic Laboratory, Department of Microbiology, Jorhat Medical College & Hospital, Jorhat, Assam, India.
Acta tropica
|March 25, 2025
概括
登革热病毒 (DENV) 血清型2在印度乔哈特最常见,影响年轻男性. 这项研究强调了该地区加强登革热监测和载体控制的必要性.
科学领域:
- 医学昆虫学 医学昆虫学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 登革热在全球范围内构成重大公共卫生威胁,特别是在热带和亚热带地区.
- 关于印度流传的登革热病毒血清型的数据有限,需要进行区域分子表征.
研究的目的:
- 为了对印度阿萨姆州乔哈特区的登革热病毒进行分子类型测试.
- 了解登革热感染的流行病学特征和血清型分布.
主要方法:
- 对非结构蛋白1 (NS1) 抗原和免疫球蛋白M (IgM) 抗体检测的酶相关免疫吸收试验 (ELISA).
- 多复合逆转录酶-聚合酶连锁反应 (RT-PCR) 用于登革热病毒血型鉴定.
- 分析病例的季节性变化,年龄和性别分布.
主要成果:
- 在1359例疑似病例中,共有370例 (27.22%) 呈阳性登革热病例.
- 登革热病毒血清型2 (DENV-2) 是主要的血清型,其次是DENV-3和DENV-1.
- 病例主要影响年龄在16-30岁的男性,发病率在9月至10月达到峰值.
结论:
- DENV-2是阿萨姆州乔哈特的主要循环血清型,观察到共感染.
- 这些发现强调了持续的登革热监测和综合载体管理战略对于早期检测和控制的重要性.
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