开发具有快速释放药物的真空压缩成型片,并比较成型和FDM3D打印片之间的溶解配置
Nirali G Patel1, Hari P Kandagatla1, Daniel Treffer2
1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY 11439, USA.
International journal of pharmaceutics
|March 25, 2025
概括
酸超溶化 (ABS) 增强了3D打印片中的药物溶解. 这项研究表明,ABS还显著增加了成型片的药物释放率,为即时释放产品提供可互换的制造选择.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 个性化和按需的平板电脑越来越多地使用FDM3D打印或融挤出纤维的成型来开发.
- 目前的方法产生缓慢的药物释放率,不适合立即释放配方.
- 酸超溶化 (ABS) 之前从3D打印的平板电脑中增强了基本药物的溶解.
研究的目的:
- 研究ABS原理在增加成型片中的药物溶解率方面的有效性.
- 为了确定酸相互作用是否可以从成型剂型中改善水溶性较差的基本药物的释放特征.
- 使用ABS方法,将成型平板电脑的溶解性能与FDM 3D打印平板电脑进行比较.
主要方法:
- 使用真空压缩成型 (VCM) 制备成型片,其中含有利 (一种基本药物) 和酸 (一种弱酸) 的纤维在1:1和1:2摩尔比率下.
- 细丝用Kollidon VA64在15%的药物负载中配制,并在高温下在真空下加工.
- 药物释放率测量并比较成型和FDM3D打印平板之间.
主要成果:
- 模具片呈现出非常高的,pH值独立的溶解率,超过90%的哈洛佩里多尔在60分钟内溶解.
- 模具片的溶解性能与使用ABS原理制备的FDM3D打印片的溶解性能相当.
- 该研究成功地证明了ABS的适用性,以改善成型片中的药物释放.
结论:
- 酸超溶解 (ABS) 原理有效地提高了模具片中的药物溶解率,类似于FDM3D打印片.
- 与ABS相结合的真空压缩成型 (VCM) 为生产立即释放剂型提供了一种可行的方法.
- 在FDM3D打印和VCM之间的选择可以基于特定的药物开发要求,因为在使用ABS时,这两种方法都产生可比的溶解配置.
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