Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Bipolar Disorder01:30

Bipolar Disorder

41
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
41
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106
Types of RNA01:20

Types of RNA

5.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
Alternative RNA Splicing02:18

Alternative RNA Splicing

20.9K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
20.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nutraceuticals: A strategy to mitigate neurotoxicity.

Advances in neurotoxicology·2026
Same author

Geriatric nutritional risk index predicts all-cause mortality in patients with heart failure: an updated systematic review and meta-analysis.

American journal of cardiovascular disease·2026
Same author

Neurochemical biomarkers in major depressive disorder.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Cytotoxicity and Coagulation Effects of Methanolic Extracts of <i>Punica granatum, Quercus infectoria, and Achillea millefolium</i>: an in vitro Study.

Journal of experimental pharmacology·2026
Same author

Nanoparticle-mediated radiosensitization in colorectal cancer radiation therapy: A narrative review on mechanisms, clinical translation, and future perspectives.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions.

Molecular neurobiology·2026

相关实验视频

Updated: May 20, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.1K

在双相情感障碍中长非编码RNAs.

Seyyed Navid Mousavinejad1, Felora Ferdosi2, Siamand Abdolghaderi3

  • 1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinica chimica acta; international journal of clinical chemistry
|March 25, 2025
PubMed
概括

长非编码RNAs (lncRNAs) 显示为双相情绪障碍的生物标志物,有助于将其与其他情绪障碍区分开来. 这些分子也可能为耐药病例提供新的治疗点.

关键词:
生物标志物 生物标志物双极性障碍是一种双极性障碍.抑郁症 抑郁症 抑郁症疯狂的疯狂 疯狂的疯狂没有编码的RNAs.在 lncRNAs 中.

更多相关视频

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.0K

相关实验视频

Last Updated: May 20, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.1K
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.0K

科学领域:

  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学
  • 精神病学是一个精神病学.

背景情况:

  • 双极性障碍包括交替出现躁狂和抑郁症,大约30%的患者有显著的抗治疗能力.
  • 目前的诊断方法可能无法完全区分双相情绪障碍与其他情绪障碍.
  • 长非编码RNAs (lncRNAs) 正在成为基因表达的关键调节者.

研究的目的:

  • 审查 lncRNAs 在双相情感障碍中的诊断和治疗潜力.
  • 探索 lncRNAs作为生物标志物,以提高诊断准确度.
  • 确定 lncRNAs 作为新型治疗策略的潜在目标.

主要方法:

  • 对调查双相情感障碍中 lncRNAs 的研究进行文献综述.
  • 分析已识别的lncRNA及其调节机制.
  • 对双相情感障碍患者的lncRNA表达模式的检查.

主要成果:

  • 一些lncRNAs,包括GAS5,FOXD3-AS1,lincRNA-p21,lincRNA-ROR和lincRNA-PINT,与双相情感障碍有关.
  • 在双相情感障碍患者中观察到的特定lncRNAs (例如GAS5,FOXD3-AS1) 的下调.
  • LncRNAs显示出作为诊断生物标志物和治疗点的潜力.

结论:

  • 作为双相情感障碍的诊断生物标志物,LncRNAs具有显著的前景.
  • 准 lncRNAs 可能会导致双相情感障碍的创新治疗方法.
  • 对lncRNA的进一步研究可以增强双相情感障碍的个性化治疗策略.