在青少年异常性关节炎中发生的状血管亡
Vaibhav S Bellary1, Jitendra Shankarlal Oswal2, Deepti Agarwal1
1Department of Clinical Immunology and Rheumatology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India.
BMJ case reports
|March 25, 2025
概括
一名患有青少年异常性关节炎 (JIA) 的儿童因葡萄糖皮质激素治疗而发展出 navicular 骨的无血管缩 (AVN). 这种罕见的并发症凸显了儿童患者长期使用类固醇的限制的必要性.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 儿科整形外科 儿科整形外科
- 儿科内分泌学 儿科内分泌学
背景情况:
- 青春期异常性关节炎 (JIA) 是儿童常见的一种自身免疫性疾病.
- 葡萄皮质皮质类药物经常用于管理JIA,但存在风险.
- 血管亡 (AVN) 是葡萄糖皮质类药物治疗的严重潜在并发症.
研究的目的:
- 在患有JIA的儿童中报告一种罕见的葡萄糖皮质激素诱导的 navicular 骨的无血管亡病例 (AVN).
- 强调在儿科患者中识别这种并发症的重要性.
- 为了突出与长期使用葡萄糖皮质激素相关的风险.
主要方法:
- 一个被诊断患有JIA的儿科患者的案例介绍.
- 临床表现,治疗和无血管缩的发展的审查.
- 讨论葡萄糖皮质醇诱导的AVN的病理生理学.
主要成果:
- 患者在接受JIA的葡萄糖皮质类药物治疗时发生了 navicular 骨的无血管缩.
- 葡萄糖皮质类药物诱导的 navicular 骨的 AVN 是儿童罕见但显著的并发症.
- 骨发育的血液供应中断是AVN的一个机制.
结论:
- 尽量减少长期使用葡萄糖皮质激素的持续时间对于管理JIA至关重要.
- 早期识别和干预对于预防AVN的长期发病率至关重要.
- 这一案例突显了一个常见的儿科治疗的关键不良影响.
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