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Viral Mutations00:36

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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在非人类灵长类动物,乌干达和卢旺达中循环的.

Tony L Goldberg, Leah A Owens, Julius Nziza

    Emerging infectious diseases
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    概括

    由Treponema pallidum pertenue引起的 Yaws 在乌干达和卢旺达的9个物种中发现了33%的灵长类动物. 这一发现突出了对该地区公共卫生和野生动物保护工作的潜在威胁.

    关键词:
    东非 非洲 东非卢旺达卢旺达卢旺达卢旺达卢旺达卢旺达卢旺达卢旺达它们属于Treponema pallidum.乌干达 乌干达 乌干达 乌干达 乌干达细菌 细菌 细菌是一种细菌.非人类灵长类动物.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈动物病是动物病.

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    科学领域:

    • 灵长类健康 灵长类健康
    • 传染性疾病 传染性疾病
    • 微生物学 微生物学

    背景情况:

    • 是一种热带感染,由Treponema pallidum pertenue细菌引起.
    • 众所周知,非人类灵长类的灵长类容易患,但非洲野生动物的患病率尚不清楚.

    研究的目的:

    • 在乌干达和卢旺达的非人类灵长类动物中调查Treponema pallidum pertenue的血清流行.
    • 确定细菌的新型基因组系,并了解该地区的流行病学动态.

    主要方法:

    • 在非人类灵长类群体中对T. pallidum pertenue抗体进行血清检测.
    • 基因组测序以确定细菌血统.
    • 在yaws爆发期间的现场观测.

    主要成果:

    • 在9种非人类灵长类动物中观察到对T. pallidum pertenue的33%的血清阳性.
    • 血清转化在致命的yaws爆发期间被记录在案.
    • 确定了一种新的T. pallidum pertenue的基因组系.

    结论:

    • 在乌干达和卢旺达的非人类灵长类动物中,病很普遍,这表明这是一个重大的公共卫生和保护问题.
    • 鉴定的新型血统可能会对疾病传播和控制产生影响.
    • 需要进一步的研究来评估对灵长类种群和潜在的动物传染病风险的全部影响.