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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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糖尿病可以影响固体瘤中的细胞免疫力.

Malgorzata A Garstka1, Lukasz Kedzierski2, Tomasz Maj3

  • 1Department of Endocrinology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710016, China; Core Research Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710016, China.

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概括

2型糖尿病 (T2D) 可能会恶化癌症免疫抑制,影响抗瘤免疫力. 这篇评论探讨了T2D如何影响固体瘤,可能是通过髓状和淋巴状细胞功能障碍.

关键词:
癌症 癌症 癌症 癌症 癌症淋巴细胞 淋巴细胞骨髓状细胞是骨髓状细胞的组成部分.瘤免疫学 瘤免疫学2 型糖尿病 2 型糖尿病

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 代谢障碍 代谢障碍 代谢障碍

背景情况:

  • 癌症和2型糖尿病 (T2D) 是全球普遍存在的,经常同时发生的疾病.
  • 免疫系统对于消除瘤至关重要,受葡萄糖等代谢因素的影响.
  • 糖尿病破坏免疫反应的调节,而癌症则建立了一个免疫抑制的瘤微环境.

研究的目的:

  • 审查T2D和实体瘤之间的相互作用.
  • 检查T2D如何可能加剧癌症诱导的免疫抑制.
  • 在这种互动中识别挑战和潜在机制.

主要方法:

  • 关于T2D和癌症免疫力的现有研究的文献综述.
  • 从临床前 (小鼠模型) 和临床 (人体组织) 研究中分析数据.
  • 探索拟议的免疫机制.

主要成果:

  • 有证据表明,T2D可能会对抗瘤免疫反应产生负面影响.
  • 鼠标模型和人类数据之间存在不一致.
  • 潜在的机制包括骨髓细胞驱动的免疫抑制和抗原呈现受损.
  • 淋巴细胞枯竭是另一个涉及的因素.

结论:

  • 二型糖尿病可能会加剧免疫抑制瘤微环境.
  • 了解这种相互作用对于开发糖尿病患者有效的癌症疗法至关重要.
  • 需要进一步的研究来澄清机制并解决数据不一致的问题.