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Updated: May 20, 2025

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鉴定了一种SNAI1增强剂RNA,该RNA驱动癌细胞可塑性

Chuannan Fan1, Qian Wang2, Peter H L Krijger3

  • 1Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

Nature communications
|March 26, 2025
PubMed
概括

像SNAI1e这样的增强器RNA (eRNA) 是基因表达的关键. 通过调节SNAI1和TGF-β信号传递,SNAI1e驱动癌细胞的可塑性,包括EMT和化学抵抗.

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