外体新型miRNA-126通过向非酒精性脂肪肝炎中的AhR-NLRP3通路来调解血管内皮功能障碍

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Updated: May 20, 2025

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Qiuhe Chen¹, Lifeng Ye¹, Liting Huang¹

¹State Key Laboratory of Traditional Chinese Medicine Syndrome, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, China.

Scientific reports

|March 26, 2025

概括

非酒精性脂肪肝炎 (NASH) 通过肝脏外体引起血管功能障碍. 外体miRNA-126激活NLRP3炎症体,导致NASH患者心血管风险.

科学领域:

心血管生物学心血管生物学
肝病学肝病学是一种肝病学.
分子医学是分子医学.

背景情况:

非酒精性脂肪肝炎 (NASH) 是一种与肥胖和心血管风险相关的日益严重的肝病.
在NASH中肝血管通信的机制尚不清楚.

研究的目的:

调查肝脏衍生的外体在NASH中的血管内皮功能障碍中的作用.
在NASH进展中确定肝血管通信的分子媒介.

主要方法:

使用缺乏甲氨酸和胆的饮食建立了一个NASH小鼠模型.
采用了体内和体外实验方法.
分析了外体miRNA和炎症酶激活.

主要成果:

纳什小鼠表现出血管功能障碍和NLRP3炎症酶激活.
外体miRNA-126被确定为一个关键的媒介.
miRNA-126向烯碳化合物受体 (AhR),增加NLRP3转录和炎症酶激活.

结论:

来自肝脏的外体,特别是外体miRNA-126,在NASH相关的血管内皮功能障碍中发挥着关键作用.
这一途径涉及向AhR并激活NLRP3炎症酶.
研究结果提供了对NASH心血管并发症和潜在治疗点的见解.

关键词:

内皮质功能障碍内皮质功能障碍异构体是什么? 异构体是什么? 外构体是什么?在NLRP3中,NLRP3是NLRP3中的一个.非酒精性脂肪肝炎 (NASH) 是一种非酒精性脂肪肝炎.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...