为新生儿重症监护病房提供人工智能引导的精确亲肠营养
Thanaphong Phongpreecha1,2,3,4, Marc Ghanem1,2,3, Jonathan D Reiss2
1Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University, Stanford, CA, USA.
Nature medicine
|March 26, 2025
概括
人工智能 (AI) 使用数据驱动系统TPN2.0优化新生儿的全亲肠营养 (TPN). 这种人工智能方法增强了精准医学,提高了安全性,并减少了接受TPN的新生儿的发病率.
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 医学中的人工智能
- 精准营养是一种精确的营养.
背景情况:
- 新生儿重症监护室 (NICU) 接受10%的新生儿,需要精确的干预.
- 人工智能 (AI) 在新生儿护理中的应用尚未得到充分探索.
- 对早产新生儿来说,全方位肠道营养 (TPN) 非常重要,但目前的方法是主观的,容易出错.
研究的目的:
- 开发和验证TPN2.0,一个数据驱动的AI系统,用于优化和标准化TPN.
- 评估TPN2.0能够在新生儿营养中实现精准医学方法的能力.
- 与当前实践相比,评估TPN2.0对安全,成本和临床结果的影响.
主要方法:
- 在斯坦福大学组建了来自5913名患者的10年的TPN组合,以训练TPN2.0.0.
- 在第二家医院的3,417名患者的外部队列上验证了TPN2.0模型.
- 采用了变压器架构来遵守指南,医生在循环中的建议.
主要成果:
- TPN2.0确定了15种TPN配方,使精准医学成为可能 (皮尔森的R=0.94与专家相比).
- 在一项盲目的研究中,医生评价TPN2.0高于当前最佳实践 (n=192).
- 推TPN2.0与降低发病率有关,而标准处方显示风险增加 (例如,OR = 3.33对于死性肠球炎).
结论:
- TPN2.0提供数据驱动,人工智能驱动的解决方案,以优化和标准化新生儿TPN.
- 该系统促进了精准医学方法,提高了安全性,并可能降低成本.
- TPN2.0允许协作,遵循指南的建议,改善对脆弱新生儿的护理.
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