在多发性骨髓瘤中衰老基因特征的预后影响
Andrea Lehoczki1,2, Otilia Menyhart3,4,5, Hajnalka Andrikovics6,7
1Doctoral College, Health Sciences Division, Semmelweis University, Budapest, Hungary. Andrea.M.Lehoczki@gmail.com.
GeroScience
|March 26, 2025
概括
细胞衰老,一个关键的衰老过程,在多发性骨髓瘤 (MM) 中发挥着作用. SenMayo基因特征有效地预测了MM患者的整体存活率,提供了宝贵的预后见解.
科学领域:
- 在瘤学瘤学.
- 老年学是一门学科.
- 分子生物学分子生物学
背景情况:
- 多发性骨髓瘤 (MM) 是一种不可治愈的血细胞恶性瘤,主要影响60岁以上的人.
- 细胞衰老,一个与衰老相关的过程,越来越多地被认为对与年龄相关的癌症起作用.
- 研究与衰老相关的基因可以为MM提供新的预后标志物.
研究的目的:
- 评估与衰老相关的基因在大量多发性骨髓瘤患者队列中的预后意义.
- 验证SenMayo基因签名作为MM的整体存活率的预测指标.
主要方法:
- 综合基因表达和临床数据来自1416MM患者在四个GEO数据集.
- 应用了MAS5规范化,JetSet探针选择和122基因SenMayo签名的加权平均表达.
- 利用考克斯回归,卡普兰-梅尔分析和多变量模型与FDR校正进行预后评估.
主要成果:
- 权重的SenMayo基因特征与MM患者的整体存活率有显著的相关性 (HR=0.6,p=1.7e-05).
- 低SenMayo表达的患者的中位生存时间为36.1个月,高表达患者的中位生存时间为57个月.
- 独立的验证证实了SenMayo签名作为一个强大的和独立的预后因素,即使调整为临床参数.
结论:
- 森迈奥基因特征是多发性骨髓瘤整体存活率的强大和独立预测指标.
- 这种特征提供了关于细胞衰老在MM进展中的作用的宝贵临床见解.
- 与衰老相关的基因表达可能作为分层MM患者风险的新生物标志物.
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