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Updated: May 20, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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ATOH8通过抑制SCD表达来赋予瘤细胞对铁亡的脆弱性

Huixiang Xiao1, Xinxing Du2, Huan Hou3

  • 1State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Cell death and differentiation
|March 26, 2025
PubMed
概括

转录因子ATOH8通过抑制醇-甲酸脱酶 (SCD) 来调节铁亡. EZH2在表观遗传上控制ATOH8,并与铁灭诱导剂一起抑制EZH2显示了癌症的治疗潜力.

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