电子显微镜分析石榴和黑 chokeberry 对大鼠急性胰腺炎的影响
E Rumeysa Hekimoglu1, Mukaddes Esrefoglu2, Seda Kirmizikan2
1Department of Histology and Embryology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Fatih, Turkey. rumeysagurbuz@gmail.com.
Journal of molecular histology
|March 26, 2025
概括
石榴和黑 chokeberry 提取物在治疗急性胰腺炎 (AP) 中表现有前途. 这些天然抗氧化剂在老鼠模型中减少了胰腺损伤,亡和氧化应激,这表明了潜在的新治疗途径.
科学领域:
- 生物医学科学 生物医学科学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 尽管正在进行研究,急性胰腺炎 (AP) 治疗仍然在很大程度上是有症状的.
- 具有抗氧化和抗炎性能的天然化合物正在探索其治疗潜力.
研究的目的:
- 为了研究Punica granatum (石榴) 和Aronia melanocarpa (黑 chokeberry) 提取物对大鼠L-氨酸诱导的急性胰腺炎的治疗作用.
- 评估这些提取物对组织病理损伤,细胞亡和氧化应激标志物的影响.
主要方法:
- 在小鼠中使用腹腔内L-氨酸给药诱导了急性胰腺炎.
- 鼠接受了口服剂量的石榴和黑 chokeberry 提取物七天.
- 使用光和电子显微镜分析胰腺组织,并对血清和组织标记物进行生物化学测试.
主要成果:
- L-氨酸诱导严重的亡性AP,标志着血清氨酶和脂酶的增加,组织总氧化剂状态 (TOS) 的升高,亡和亡.
- 电子显微镜在AP模型中揭示了退化的有机细胞和亡体.
- 石榴和黑 chokeberry 提取物都显著降低了他的病理损伤,亡率和TOS水平.
结论:
- 普尼卡·格拉纳图姆和阿罗尼亚·梅拉诺卡帕的提取物在治疗急性胰腺炎方面表现出有益的作用.
- 这些发现表明,石榴和黑 chokeberry 通过减轻氧化应激和炎症,在AP治疗中具有治疗潜力.
- 这项研究为开发使用这些天然提取物治疗AP的新疗法提供了基础.
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