Lacticaseibacillus rhamnosus G7通过调节肠道微生物群来缓解DSS诱导的性结肠炎
Jianlong Lao1,2, Man Chen1, Shuping Yan1
1College of Coastal Agricultural Sciences, Department of Veterinary Medicine, Guangdong Ocean University, Zhanjiang, 524088, China.
BMC microbiology
|March 26, 2025
概括
从酸奶中获得的益生菌Lacticaseibacillus rhamnosus G7,在结肠炎模型中有效降低了炎症并改善了肠道健康. 这种有益的细菌有望预防肠道疾病.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种影响人类和动物健康的重要肠道炎症疾病.
- 虽然益生菌用于肠道炎症,但菌株特异性功能尚不清楚.
- 从传统的酸奶中获取的Lacticaseibacillus rhamnosus G7被调查其治疗潜力.
研究的目的:
- 在体外环境和大肠炎小鼠模型中评估Lacticaseibacillus rhamnosus G7的疗效.
- 评估G7对炎症标志物,肠道组织学和微生物组成的影响.
主要方法:
- 在体外评估Lacticaseibacillus rhamnosus G7的耐受性和安全性.
- 在小鼠中诱导大肠炎和随后的G7治疗.
- 疾病活动指数 (DAI) 的测量,促炎性细胞因子 (IL-1β,IL-6,TNF-α),抗炎性细胞因子 (IL-10) 和组织病理学得分.
- 使用16S rRNA测序对肠道微生物组成的分析.
主要成果:
- G7在体外表现出良好的耐受性和安全性.
- 在体内,G7治疗缓解了结肠炎症状,包括体重减轻,结肠缩短和减少DAI得分.
- G7显著降低了促炎性细胞因子水平 (IL-1β,IL-6,TNF-α) 并改善了他的病理学评分.
- G7治疗导致抗炎细胞因子IL-10的水平增加.
- 通过增加 Faecalibaculum 和减少 Bacteroides 和 Escherichia_Shigella 丰度,G7 重新平衡了肠道微生物群.
结论:
- 在大肠炎的小鼠模型中,Lacticaseibacillus rhamnosus G7表现出显著的抗炎作用.
- 通过调节肠道微生物群和免疫反应,G7显示出作为预防和治疗性结肠炎的治疗剂的潜力.
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