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肠道失生症:在乳病中引起肠道炎症的原因或后果?
Stefano Leo1, Maureen M Leonard2,3,4, Francesco Valitutti5
1European Biomedical Research Institute of Salerno, Salerno, Italy.
乳病 (CeD) 的发病包括肠道微生物群,但无论它是什么.
科学领域:
- 胃肠道学和免疫学
- 微生物组研究 微生物组研究
- 计算生物学 计算生物学
背景情况:
- 病 (CeD) 是一种由引发的,在遗传敏感个体中发生的免疫媒介疾病.
- 越来越多的CeD患病率表明,除了遗传和质之外的因素有助于其发展.
- 肠道微生物群在CeD发病过程中的作用尚不清楚,关于它是原因还是后果的争论仍在进行中.
研究的目的:
- 审查关于肠道微生物群在CeD病变发生中的作用的当前文献.
- 调查肠道失调是否是乳性肠道病变的原因或后果.
- 探索多组学和人工智能 (AI) 在CeD诊断和个性化医学中的潜力.
主要方法:
- 2007年至2023年间在PubMed数据库中发表的研究的文献综述.
- 专注于潜在的出生队列研究,将肠道微生物群失生症与CeD联系起来.
- 在CeD研究中讨论多主题和AI应用.
主要成果:
- 在CeD患者中经常观察到肠道微生物群失生症.
- 证据表明,宿主基因,质暴露和CeD的肠道微生物组之间存在复杂的相互作用.
- 多组学和人工智能对揭开微生物组的作用和改善CeD诊断具有前途.
结论:
- 肠道微生物对CeD病原体的贡献需要进一步阐明.
- 多原子方法对于理解CeD中微生物组的表观遗传作用至关重要.
- 与AI整合多omics可以带来增强的CeD诊断和个性化治疗策略.
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