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精子DNA碎片化与农场动物生育能力参数之间的关联:系统性审查和元分析

Kenneth Owoicho Abah¹, Zuzanna Ligocka-Kowalczyk², Joy Iyojo Itodo³

¹Department of Reproduction and Clinic of Farm Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Plac Grunwaldzki 49, 50‑366, Wroclaw, Poland. kenneth.abah@upwr.edu.pl.

BMC veterinary research

|March 26, 2025

概括

精子DNA碎片化 (SDF) 对公牛和马等农场动物的男性生育能力产生负面影响. 纳入SDF测试可以改善育种健全性评估和人工育种计划的雄性选择.

科学领域:

生殖生物学生殖生物学
动物科学动物科学
遗传学是一个遗传学.

背景情况:

男性的生育能力对畜牧业至关重要,具有重大的经济影响.
精子DNA完整性是影响哺乳动物生育能力的已知因素.
常规的精液分析往往无法检测DNA损伤,并与生育结果相关联.

研究的目的:

通过元分析,评估精子DNA碎片化 (SDF) 与农场动物的男性生育能力之间的关联.
确定SDF测定是否可以提高育种健全性评估的准确性.

主要方法:

进行了对30项调查SDF和农场动物生育能力的研究的元分析.
搜索了科学数据库,包括PubMed,谷歌学者和Springer链接.
根据动物物种和SDF检测方法分层结果.

主要成果:

在跨物种的SDF和男性生育能力之间发现了整体负相关性 (COR = -0.46).
在公牛 (COR = -0.47) 和马匹 (COR = -0.54) 中观察到显著的负相关性.
与高生育率组相比,低生育率动物的SDF水平显著更高 (SMD = 0.85).

结论:

SDF测定显示了在人工育种计划中提高选择高质量的繁殖雄性的精度的潜力.
需要使用标准化的方法和适当的样本大小进行进一步的研究,才能充分了解SDF对农场动物生育能力的影响.

关键词:

动物繁殖动物的繁殖进行元分析分析.精液质量精液质量精子的DNA受损.亚生育能力不能生育

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