癌症免疫治疗中的营养条件和PFS和OS:MOUSEION-010元分析
Elsa Vitale1, Lorenza Maistrello2, Alessandro Rizzo3
1Scientific Directorate, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Immunotherapy
|March 26, 2025
概括
营养状况影响癌症患者的免疫检查点抑制剂 (ICI). 控制营养状况 (CONUT) 评分显著预测了无进展生存率 (PFS) 和总生存率 (OS),与PNI和GNRI不同. 营养不良可能会降低治疗疗效和生存率.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 免疫疗法研究 免疫疗法研究
背景情况:
- 对于接受免疫检查点抑制剂 (ICI) 治疗的癌症患者,营养状况至关重要.
- 评估营养状况有助于预测瘤学中的临床结果.
研究的目的:
- 评估ICI治疗的癌症患者的营养状况和临床结果 (无进展生存率 (PFS) 和整体生存率 (OS)) 之间的关联.
- 为了比较预后营养指数 (PNI),老年营养风险指数 (GNRI) 和控制营养状况 (CONUT) 评分的预测值.
主要方法:
- 通过使用Embase,PubMed,Scopus和Web of Science进行了对研究的元分析.
- 用PNI,GNRI和CONUT指数进行营养状况评估.
- 进行了统计分析以确定与PFS和OS的关联,包括评估出版偏差.
主要成果:
- PNI和GNRI得分没有显示与PFS或OS有显著的关联.
- 该CONUT得分显示了与改善的PFS (Z=4.04,p<0.01) 和OS (Z=4.24,p<0.01) 的显著关联.
- 对于OS预测 (β=1.89,p=0.028) 发现了出版偏差,研究数量缺乏足够的统计能力来得出最终结论.
结论:
- 营养不良会对晚期癌症患者产生负面影响,可能会降低身体功能和治疗遵守性.
- 对于接受ICI的癌症患者来说,CONUT得分可以作为一个有价值的预后标记.
- 需要进一步进行具有足够统计能力的研究来证实这些发现.
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