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Updated: May 20, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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药物诱导的肝损伤中的表观遗传修饰:系统性审查

Romina Lorena de Los Santos-Fernández1, Antonio Segovia-Zafra1,2, Guillermo Paz-López3

  • 1Servicio de Aparato Digestivo y Farmacología clínica, Instituto de Investigación Biomédica de Málaga-IBIMA Plataforma BIONAND, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.

British journal of clinical pharmacology
|March 26, 2025
PubMed
概括

表观遗传因素,特别是DNA甲基化,与药物诱导的肺结核药物造成的肝损伤有关. 特定基因促进体和可转移元素的变化可以作为这种疾病的生物标志物.

关键词:
通过DNA甲基化.抗结核药物诱导的肝损伤药物诱导的肝损伤是由药物引起的.表观遗传调节 表观遗传调节肝毒性 肝毒性 肝毒性奇特的药物诱导性肝损伤.肝脏损伤 肝脏损伤 肝脏损伤

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