C-反应性蛋白与住院儿童患有呼吸道共囊病毒支气管炎的严重程度有关
Assaf Adar1, Aviv D Goldbart2, Nitzan Burrack3
1Department of Pediatrics B, Saban Children's Hospital, Soroka University Medical Center, Beer Sheva, Israel, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
The Israel Medical Association journal : IMAJ
|March 26, 2025
概括
患有呼吸道同胞病毒 (RSV) 支气管炎的住院婴儿中C-反应蛋白 (CRP) 水平升高表明疾病严重程度增加和并发症风险更高. 这一发现有助于预测RSV感染的幼儿的结果.
科学领域:
- 儿童传染病 儿童传染病
- 临床生物化学 临床生物化学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 急性支气管炎主要是由呼吸道同胞病毒 (RSV) 引起的,是儿童住院的主要原因.
- 当前的诊断实践往往依赖于临床评估,实验室评估的确立有效性有限.
- 了解与疾病严重程度相关的生物标志物对于有效管理至关重要.
研究的目的:
- 调查入院时C-反应蛋白 (CRP) 血清水平与RSV支气管炎住院儿童疾病严重程度之间的相关性.
- 确定CRP对疾病并发症和资源利用的潜在预测价值.
主要方法:
- 追溯队列研究的设计.
- 包括1874名在2018年至2022年期间因RSV支气管炎住院的0-24个月龄的儿童.
- 在入院时测量的C反应蛋白 (CRP) 血清水平的分析.
主要成果:
- 患有高CRP (> 1.92 mg/dl) 的儿童年龄较大,肺炎,尿路感染 (UTI) 和急性中耳炎 (AOM) 的发病率较高.
- 升高的CRP与儿科重症监护室 (PICU) 的入院率,抗生素治疗和更长的住院时间的增加有关.
- 多变量分析证实CRP是尿路感染,PICU入院,肺炎和长时间住院的预测因素,为这些结果确定了特定的CRP值.
结论:
- 在住院时C反应性蛋白 (CRP) 水平升高与儿科RSV支气管炎的疾病严重程度增加有显著联系.
- 较高的CRP水平与肺炎,尿道感染和AOM等并发症的可能性更高相关.
- CRP作为一个有价值的生物标志物,用于预测不良结果,并指导RSV支气管炎住院儿童的临床管理.
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