临床实践中的精神病遗传学:精神卫生专业人员必需的知识
Aaron D Besterman1, Mohamed A Alnor1, Mauricio Castaño1
1University of California San Diego Department of Psychiatry, Rady Children's Hospital San Diego, and Rady Children's Institute for Genomic Medicine, San Diego (Besterman); School of Medicine, University of Khartoum, Khartoum, Sudan and American Center for Psychiatry and Neurology, UAE (Alnor); Department of Mental Health and Human Behaviour, University of Caldas, Manizales, Caldas, Colombia (Castaño); Cambridge Health Alliance and Harvard Medical School, Cambridge, MA (DeLisi); Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Grice); National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD (Lohoff); Department of Child and Youth Psychiatry and Psychology, Amsterdam UMC, Amsterdam Reproduction & Development Research Institute, Amsterdam Public Health Research Institute, The Netherlands (Middeldorp); Pharmacogenetics Research Clinic, Centre for Addiction and Mental Health, Toronto, Canada and Department of Psychiatry, University of Toronto, Canada (Müller); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, U.K., and Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), Psychiatry Section, University of Palermo, Palermo, Italy (Quattrone); Departments of Psychiatry and Medical and Molecular Genetics, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis (Nurnberger); Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (Nurmi); Department of Psychiatry, University of Alberta Faculty of Medicine and Dentistry, Edmonton (Ross); Center for Autism and Neurodevelopment, Department of Psychiatry, University of Florida College of Medicine, Gainesville (Soda); Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany (Schulze); Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada (Trost); Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili-CERCA, Universitat Rovira i Virgili, CIBERSAM-Instituto de Salud Carlos III. Reus, Spain (Vilella); Department of Psychiatry, University of Oxford, and Mater Research Institute, Faculty of Medicine, University of Queensland and Metro South Addiction and Mental Health Service, Brisbane, Australia (Yap); Neurogenetics Section, Molecular Brain Sciences Department, Centre for Addiction and Mental Health, Department of Psychiatry and Institute of Medical Science, University of Toronto, Ontario, Canada (Zai); Precision Medicine in Autism (PRISMA) Group, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Faculty of Medicine and Dentistry; Women and Children's Health Research Institute; Neuroscience and Mental Health Institute; University of Alberta; Alberta Health Services; CASA Mental Health; Edmonton, AB, Canada (Moreno-De-Luca).
精神病遗传学的进步为心理健康临床医生提供了新的工具. 将遗传见解与环境因素相结合,可以改善患者的护理和精神疾病风险评估.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 临床实践 临床实践
背景情况:
- 精神病遗传学正在迅速发展.
- 心理健康临床医生需要将新的遗传发现纳入实践.
研究的目的:
- 为将精神病遗传学的进展纳入临床实践提供建议.
- 在精神病遗传学中的优先主题上教育心理健康临床医生.
主要方法:
- 国际精神病遗传学学会教育委员会建立共识.
- 专家对包括家族聚合,遗传变异,表观遗传学,基因环境相互作用,药物基因组学,遗传咨询和伦理/社会影响等主题的专家审查.
主要成果:
- 了解基因架构对于精神疾病至关重要.
- 遗传信息有助于风险评估,诊断,治疗和患者教育.
- 一个细微的,整体的方法整合遗传和非遗传因素是必不可少的.
结论:
- 临床医生必须了解精神病遗传学的进展.
- 合作和有效的沟通是负责任地利用遗传信息的关键.
- 建议对遗传和非遗传因素的相互作用采取平衡的观点.
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