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相关概念视频

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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基于凝的瘤组织微型架构重塑树突细胞代谢特征和功能

Brian Chesney Quartey1,2, Jiranuwat Sapudom1, Paul Sean Tipay3

  • 1Laboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi, 129188, UAE.

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概括

细胞外矩阵对齐影响树突细胞 (DC) 功能,损害不成熟的DC迁移和T细胞激活. 成熟的DCs仍然不受影响,这表明在癌症治疗中免疫调节的特定阶段的作用.

关键词:
细胞迁移 细胞迁移树突细胞的新陈代谢细胞外矩阵对齐调整免疫调节的免疫调节瘤微环境是一个微环境.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物材料科学 生物材料科学
  • 细胞生物学 细胞生物学

背景情况:

  • 细胞外基质 (ECM) 对免疫细胞功能至关重要,其重塑与癌症等疾病有关.
  • 在ECM内的纤维状对齐是病理状况的关键特征,影响免疫反应.

研究的目的:

  • 研究细胞外矩阵 (ECM) 对齐对树突细胞 (DC) 行为和功能的影响.
  • 了解控制的ECM异性质如何影响DC免疫调节特性和T细胞相互作用.

主要方法:

  • 使用3D仿生原基质矩阵与受控的纤维异性,以模仿ECM对齐.
  • 分析了不成熟和成熟的DC反应,包括表面标记物表达,化学激素分泌,转录和代谢.
  • 进行了T细胞共同培养实验,以评估ECM对齐对T细胞激活的影响.

主要成果:

  • 在对齐矩阵中不成熟的DC显示了增强的CD86和HLA-DR表达和增加的化学激素分泌,但减少了氧化酸化和ATP产生,导致迁移受损.
  • 成熟的DC表现出对ECM对齐的最小灵敏度,保持一致的功能配置文件.
  • 在共同培养实验中,ECM对齐抑制了T细胞激活和增殖.

结论:

  • 细胞外矩阵对齐不同地影响树突细胞 (DC) 功能,基于它们的成熟状态.
  • ECM对齐可以损害DC迁移和T细胞反应,突出其在病理背景下的免疫调节作用.
  • 这些发现为开发向癌症和炎症疾病的疗法提供了洞察力,通过调节瘤微环境来调节癌症和炎症疾病.