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人类和小鼠模型脑动脉瘤在单细胞分辨率上的差异

Hang Ji^1,2, Guicheng Kuang¹, Hailan Yang¹

¹Department of Neurosurgery, Sichuan University West China Hospital, Chengdu, China.

Frontiers in cell and developmental biology

|March 26, 2025

概括

人类和小鼠脑动脉瘤模型显示了血管光滑肌细胞,中性粒细胞和巨细胞的关键差异. 这些发现突出了差异,并建议优化小鼠模型以获得更好的人类相关性.

科学领域:

生物医学研究的研究.
基因组学就是基因组学.
血管生物学血管生物学

背景情况:

鼠标模型被广泛用于脑动脉瘤 (CA) 研究.
然而,其反映人类CA的准确性仍然不清楚.

研究的目的:

为了研究人类和小鼠CA模型之间的细胞和分子差异.
确定改善小鼠模型对人类相关性的潜在领域.

主要方法:

使用单细胞RNA测序 (scRNA-seq) 数据集成.
进行了轨迹和基因调节网络分析.
采用统一的多元体近似和投影 (UMAP) 进行可视化.

主要成果:

在血管光滑肌细胞 (vSMCs),单细胞/巨细胞和中性粒细胞中发现的不一致性.
人类的vSMCs表现出类似纤维细胞的表型,与小鼠的vSMC不同.
与小鼠 (CCL) 相比,人类CA表现出更严重的炎症和明显的中性粒细胞招募模式 (CXCL8).
人类未破裂的CA中的巨体表达了更高的M2标记物.

结论:

在人类和小鼠CA模型之间发现了微妙但显著的差异.
这些发现可以指导对小鼠CA模型的优化,以加强翻译研究.

关键词:

大脑动脉瘤是什么意思人类 CA 人类 CA 这是一种炎症炎症炎症炎症.鼠标模型 CA CA 的模型一个单细胞RNA测序.

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