唐氏综合症患者的眼睛表现:系统性审查和元分析
Jessica A Beresford-Webb1, Emily Charlesworth2, Shahina Pardhan2
1Department of Psychiatry, University of Cambridge, Cambridge, UK.
Journal of ophthalmology
|March 26, 2025
概括
在唐氏综合征 (DS) 患者中,眼睛问题很常见. 这次审查发现折射误差,视障和透镜不透明是最常见的,这突显了整个寿命内需要全面的眼睛护理的需要.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 唐氏综合症 (DS) 是导致智力障碍的主要遗传原因.
- 在DS患者 (pwDS) 中,眼部表现很常见.
- 在pwds中没有对眼部疾病的全面寿命审查.
研究的目的:
- 系统地审查和对所有年龄段唐氏综合征患者眼部表现的流行情况进行元分析.
- 识别最常见的眼部疾病和影响其患病率的潜在因素.
主要方法:
- 在PubMed,Medline,Embase,Web of Science和Scopus搜索了观察研究.
- 使用随机效应模型对特定眼部表现的综合发病率进行了元分析.
- 对于缺乏足够的流行数据的疾病,采用了叙事方法.
主要成果:
- 包括54项研究,涵盖从出生到88.7岁的个体.
- 患病率最高的是:折射误差 (69.97%),眼 (31.41%),透镜不透明 (13.79%),阴影 (12.72%),角质球 (9.34%).
- 其他发现包括透镜/角膜变化,后部段异常 (如青光眼) 和布拉什菲尔德斑点.
结论:
- 在pwDS的眼部表现是常见的和多样化的.
- 年龄,种族和智力障碍的严重程度可能会影响患病率.
- 强调定期,全面的眼科检查对患有唐氏综合征的人的重要性.
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