单个代理对Mycobacterium avium复杂肺部疾病的时间转换到文化转换的影响
Joong-Yub Kim1,2, Yunhee Choi3, Jae-Joon Yim4,5
1Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Open forum infectious diseases
|March 26, 2025
概括
没有实现培养转换的Mycobacterium avium复杂肺病患者年龄较大,有特定的治疗差异. 在这个患者队列中,利芬素的使用与较低的培养转化率有关.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 菌复合体 (MAC) 肺部疾病是一种具有挑战性的感染.
- 实现培养转换是一个关键的治疗终点.
- 影响治疗结果的因素需要进一步研究.
研究的目的:
- 确定患者特征和与未能在MAC肺部疾病中实现培养转换相关的治疗因素.
- 评估单个药物对培养转换时间的影响.
主要方法:
- 对534名为MAC肺部疾病治疗的患者进行了回顾性队列研究.
- 对患者人口统计,疾病特征和治疗方案的分析.
- 时间变化的考克斯回归分析,以评估药物对培养物转换的影响.
主要成果:
- 失败培养转换的患者年龄较大,更有可能是男性,并且有.
- 这些患者接受了更频繁的克洛法齐明和阿米诺糖化物,但较少的里芬皮辛.
- 利芬素的使用与减少的培养转化率相关 (aHR,0.959;P = .027).
结论:
- 年龄较大,男性性别和空腔存在与MAC肺部疾病中较差的培养转换结果有关.
- 利芬素可能对实现培养转换产生负面影响,需要进一步研究.
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