抗生素持续时间对肠道微生物组合和抗菌素耐药性的影响:BALANCE随机对照试验的子研究
Eric Armstrong1, Maria Kulikova1, Noelle Yee1
1Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Open forum infectious diseases
|March 26, 2025
概括
较短的抗生素疗程 (7天) 与细菌病患者的较长疗程 (14天) 相比,没有显著改变肠道微生物群多样性或抗菌素耐药性基因 (ARG) 携带. 由于样本规模较小,需要进一步研究.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 临床医学 临床医学
背景情况:
- 维持肠道微生物群的多样性和减少抗菌素耐药性基因 (ARG) 对于打击抗菌素耐药性至关重要.
- 抗生素使用显著影响肠道微生物群和ARG载体.
研究的目的:
- 为了比较肠道微生物组的破坏和ARG载体在7天和14天的细菌血症抗生素治疗后.
- 评估抗生素持续时间对肠道微生物群多样性和ARG载体的影响,在BALANCE试验的副研究中.
主要方法:
- 在BALANCE随机对照试验的一个子研究中,分析了接受7天或14天抗生素治疗的患者的直肠拭子.
- 使用元基因组测序来描述肠道微生物组和ARG.
- 测量的主要结果是第7天和第14天之间的肠道微生物群多样性的变化.
主要成果:
- 在7天和14天的抗生素组之间没有观察到肠道微生物群多样性变化的显著差异 (P = .49).
- 在第7天和第14天的ARG丰度和个体ARG水平的变化在治疗持续时间之间没有差异.
- 从入学到第7天,没有检测到肠道微生物群多样性或ARG携带的变化.
结论:
- 这项副研究没有发现14天的肠道微生物组破坏或ARG载体较大,而7天的抗生素对细菌血症.
- 限制包括小样本规模和治疗组之间的不平衡,需要谨慎的解释.
- 这些发现表明,较短的抗生素持续时间可能不会加剧微生物组破坏或ARG载体,但需要进行更大规模的研究.
更多相关视频
相关概念视频
Antibiotic Selection
52.1K
Overview
52.1K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
103
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
103
Genomic DNA in Prokaryotes
43.2K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.2K
Anatomy of the Intestines
71.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.1K
Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K
Bacterial Transformation
55.0K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.0K


